Evaluation of a neurovascular device to minimize vessel intima damage - ON-1110

Genre de projet: Recherche
Discipline(s) souhaitée(s): Génie -biomédical, Génie, Biologie, Sciences de la vie
Entreprise: Sensible Vascular Incorporation
Durée du projet: 6 mois à 1 an
Date souhaitée de début: Dès que possible
Langue exigée: Anglais
Emplacement(s): Hamilton, ON, Canada
Nombre de postes: 1
Niveau de scolarité désiré: MaîtriseDoctoratRecherche postdoctorale
Ouvert aux candidatures de personnes inscrites à un établissement à l’extérieur du Canada: No

Au sujet de l’entreprise: 

Sensible Vascular is developing a next generation thrombectomy device to evolve stroke care. Our patent-pending technology overcomes critical limitations of current systems by increasing first pass efficacy of clot retrieval, while reducing vessel trauma and embolic complications. The goal: optimize patient outcomes while minimizing risk.

Veuillez décrire le projet.: 

This research project centers on the design, development, and rigorous preclinical evaluation of a novel neurovascular intervention device aimed at minimizing intimal injury to cerebral blood vessels—an area of critical unmet need in endovascular therapies. Intimal trauma during mechanical thrombectomy or catheter navigation can result in serious adverse events, including vessel dissection, restenosis, or thrombotic complications. Current clinical tools do not adequately address this risk, particularly in delicate neurovascular anatomy.
The candidate will begin with an extensive systematic literature review to critically evaluate existing test methods, in-vitro models, and clinical outcomes related to intimal damage in neurovascular interventions. Building upon this foundational knowledge, the student will then:
• Design and construct a physiologically relevant in-vitro test platform, replicating the structural and mechanical properties of cerebral vessels under both healthy and disease-mimicking conditions.
• Develop or adapt quantitative assessment tools (e.g., imaging modalities, histopathological scoring systems, material-tissue interaction metrics) to evaluate endothelial and sub-endothelial damage.
• Optimize and test multiple prototype iterations of the device to characterize its biomechanical performance and compare outcomes against clinically used benchmark devices.
• Apply principles of Design for Manufacturability (DFM) and translational strategy to inform potential pathways to clinical use.
This interdisciplinary project will require strong engagement with biomedical engineering, vascular biology, materials science, and device prototyping, offering opportunities to publish high-impact research and contribute to real-world medical device innovation. Collaboration with clinical advisors and industry partners will provide additional insight into regulatory, usability, and commercialization considerations.

Expertise ou compétences exigées: 

• Biomedical Engineering or Mechanical Engineering (with biomedical focus)
• Knowledge of vascular physiology, particularly cerebral vessel structure and disease
• Experience with literature reviews and scientific writing
• Familiarity with in-vitro test development, fluid dynamics, or vascular models
• Skills in CAD, prototyping, and basic machining or 3D printing (preferred)
• Experience with microscopy or histology (asset but not mandatory)
• Analytical skills for data acquisition and interpretation